Metasploit Framework is the leading open-source exploitation framework. Even though most CySA+ tasks are defensive, candidates must understand Metasploit because it is the canonical tool attackers use, and its modules drive a large share of detection signatures.
Core concepts:
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Exploits vs payloads vs encoders vs auxiliaries vs post modules.
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Meterpreter — the post-exploitation in-memory agent.
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msfvenom — payload generator (PE, ELF, JSP, ASPX, raw shellcode).
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db_nmap — automatic ingestion of Nmap results into the workspace.
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Pivoting and routing through compromised hosts.